Takeda Pharmaceutical Company
|Founded||Doshomachi, Osaka, Japan (June 12, 1781)|
|Headquarters||1-1, Doshomachi Yonchome, Chuo-ku, Osaka, Japan|
|Key people||Yasuchika Hasegawa (President & CEO)|
|Revenue||¥1,557,267 million (FY 2012)* 1|
|Operating income||¥122,505 million (FY 2012)* 1|
|Net income||¥131,244 million (FY 2012)* 1|
|Total assets||¥3,955,599 million (FY 2012)* 1|
|Total equity||¥2,223,359 million (FY 2012)* 1|
|Website||takeda.com (Global website)|
|Footnotes / references
Takeda Pharmaceutical Company Limited (武田薬品工業株式会社 Takeda Yakuhin Kōgyō Kabushiki-gaisha?) is the largest pharmaceutical company in Japan and Asia and a top 15 pharmaceutical company. The company has over 30,000 employees worldwide and achieved $16.2 billion USD in revenue during the 2012 fiscal year.1 The company is focused on metabolic disorders, gastroenterology, neurology, inflammation, as well as oncology through its independent subsidiary, Millennium: The Takeda Oncology Company.2 Its headquarters is located in Chuo-ku, Osaka, and it has an office in Nihonbashi, Chuo, Tokyo.34 In January 2012, Fortune Magazine ranked the Takeda Oncology Company as one of the 100 best companies to work for in the United States.
Takeda Pharmaceuticals was founded on June 12, 1781 and was incorporated on January 29, 1925.
In 1977, Takeda first entered the U.S. pharmaceutical market by developing a joint venture with Abbott Laboratories called TAP Pharmaceuticals.5 Through TAP Pharmaceuticals, Takeda and Abbott launched the blockbusters Lupron (leuprolide) in 1985 and Prevacid (lansoprazole) in 1995.
One of the firm's mainstay drugs is Actos, a compound in the thiazolidinedione class of drugs used in the treatment of type 2 diabetes. Launched in 1999, Actos has become the best-selling diabetes drug in the world with $4 billion USD in sales during the 2008 fiscal year.6
In February 2005, Takeda announced its acquisition of San Diego, California-based Syrrx, a company specializing in high-throughput X-ray crystallography, for $270 million.7
In March 2008, Takeda and Abbott Laboratories announced plans to conclude their 30-year old joint venture, TAP Pharmaceuticals, that had over $3 billion in sales in its final year. The split resulted in Abbott acquiring U.S. rights to Lupron and the drug's support staff. On the other hand, Takeda received rights to Prevacid and TAP's pipeline candidates. The move also increased Takeda's headcount by 3,000 employees.9
In April 2008, Takeda announced that it was acquiring Millennium Pharmaceuticals of Cambridge, Massachusetts, a company specializing in cancer drug research, for $8.8 billion. The acquisition brought in Velcade, a drug indicated for hematological malignancies, as well as a portfolio of pipeline candidates in the oncology, inflammation, and cardiovascular therapeutic areas. Millennium now operates as an independent subsidiary, serving as the global center of excellence in oncology under its new name: "Millennium: The Takeda Oncology Company." 10
On April 11, 2012, Takeda Pharmaceutical and URL Pharma announced that Takeda will acquire URL Pharma for $800 million. The acquisition is expected to be completed within 60 days.
On 30 September 2014, Takeda announced its intention to expand a collaboration with MacroGenics, valued up to $1.6 billion. The collbaoration will focus on the co-development of the preclinical autoimmune compound MGD010. MGD010 is a therapy which targets the B-cell surface proteins CD32B and CD79B, and is indicated for lupus and rheumatoid arthritis.15
Takeda operates two primary bases in Japan in Osaka and Tokyo. Its United States subsidiary is based in Deerfield, Illinois, and all Global Operations outside of Japan and U.S. are based in Opfikon (Zurich), Switzerland. The company maintains research & development sites in Osaka and Tsukuba, Japan; San Diego and San Francisco, United States; Cambridge, United Kingdom; and Singapore.16
The company has manufacturing facilities in Japan, China, Indonesia, Italy, and Ireland.17 Following the Nycomed acquisition, the Takeda manufacturing sites have been extended with facilities in Argentina, Austria, Belgium, Brazil, Denmark, Estonia, Germany, Mexico, Norway and Poland. Takeda has overseas marketing presences in the U.S., UK, France, Italy, Germany, Austria, Switzerland, Spain, China, Taiwan, Philippines, Thailand, Indonesia, and Singapore. It has recentlywhen? announced its first foray into Canada, Portugal, Spain, Mexico, and Ireland.17
Some of the key products that Takeda produces on behalf of partners include:18
- Actos (pioglitazone) - Type 2 Diabetes 19
- Amitiza (lubiprostone) - Chronic idiopathic constipation
- Basen (voglibose) - Type 2 Diabetes
- Benet (risedronic acid) - Osteoporosis (Japan)
- Blopress (candesartan) - Hypertension
- Enbrel (etanercept) - Inflammatory diseases (Japan)
- Dexilant (dexlansoprazole) - Gastroesophageal reflux disease - name changed to Dexilant in U.S.
- Lupron/Leuplin (leuprorelin) - GnRH agonist for prostate cancer and endometriosis
- Prevacid/Takepron (lansoprazole) - Gastroesophageal reflux disease
- Rozerem (ramelteon) - Insomnia
- Uloric (febuxostat) - Gout
- Velcade (bortezomib) - Multiple myeloma and mantle cell lymphoma (Millennium Pharmaceuticals)
- "Financial Results for Fiscal 2012" (PDF). Takeda Pharmaceutical Company Limited. May 9, 2013. Retrieved June 13, 2013.
- "Takeda Initiates Cardiovascular Outcomes Trial for Alogliptin, An Investigational Treatment for Type 2 Diabetes". Newsblaze.com. 2009-08-28. Retrieved 2010-09-18.
- "FAQ." Takeda Pharmaceutical Company. Retrieved on February 2, 2011. "Q : Where is Takeda located? A : The Head Office is located in Osaka, Japan, and the Tokyo Head Office is located in Tokyo, Japan."
- "Overview." Takeda Pharmaceutical Company. Retrieved on February 2, 2011. "Headquarters Head Office 1-1, Doshomachi 4-chome, Chuo-ku, Osaka 540-8645" and "Tokyo Head Office 12-10, Nihonbashi 2-chome, Chuo-ku, Tokyo 103-8668"
- "TAP Pharmaceutical Products, Inc.: Private Company Information - BusinessWeek". Investing.businessweek.com. 2008-04-30. Retrieved 2010-09-18.
- Decker, Susan (2009-07-06). "Takeda Sues Torrent to Stop Generic Copy of Actos Diabetes Pill". Bloomberg. Retrieved 2010-09-18.
- Somers, Terri (2005-02-08). "Japanese drug giant taking over Syrrx here | The San Diego Union-Tribune". Signonsandiego.com. Retrieved 2010-09-18.
- "Takeda, Amgen in exclusive tie-up for Japanese market". MarketWatch. 2008-02-04. Retrieved 2010-09-18.
- Marrazzo, Amanda (2008-05-15). "Featured Articles From The Chicago Tribune". Archives.chicagotribune.com. Retrieved 2010-09-18.
- "MILLENNIUM: The Takeda Oncology Company | About Millennium | Our History". Mlnm.com. Retrieved 2010-09-18.
- staff (2008-06-15). "Takeda Signs On as Alnylam's Asian Partner for $150M Upfront". Genetic Engineering & Biotechnology News (print) (Mary Ann Liebert, Inc.). p. 14.
- Hirschler, Ben (May 25, 2012). "Farmacêutica Takeda comprará Multilab por até R$ 540 mi". Grupo Abril (in Portuguese). Exame. Retrieved January 27, 2013.
- "Locations | Worldwide | Takeda Pharmaceutical Company Limited". Takedaism.com. Retrieved 2010-09-18.
- "By Business | Worldwide | Takeda Pharmaceutical Company Limited". Takedaism.com. Retrieved 2010-09-18.
- "Annual Reports | Investor Information | Takeda Pharmaceutical Company Limited". Takeda.com. Retrieved 2010-09-18.
- April 2014 The U.S District Court in western Louisiana ordered a $6 billion penalty for Takeda and $3 billion for its business partner and co-defendant Eli Lilly and Company. It also ordered $1.5 million in compensatory damages in favour of the plaintiff. The legal fight turned on whether Actos, which is a drug used to treat type-two diabetes, caused a patient's bladder cancer and by implication was responsible for other cases of the cancer. http://www.cbc.ca/news/business/actos-cancer-link-nets-eli-lilly-takeda-9b-fine-1.2602635
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