Liquid fluorine at cryogenic temperatures
|Name, symbol||fluorine, F|
|Pronunciation||//, //, //
|Appearance||gas: very pale yellow
liquid: bright yellow
solid: alpha is opaque, beta is transparent
|Fluorine in the periodic table|
|Standard atomic weight||18.998403163(6)|
|Element category||diatomic nonmetal|
|Group, period, block||group 17 (halogens), period 2, p-block|
|Electron configuration||[He] 2s2 2p51
per shell: 2, 7
|Melting point||53.48 K (−219.67 °C, −363.41 °F)2|
|Boiling point||85.03 K (−188.11 °C, −306.60 °F)2|
|Density||1.696 g/L3 (at 0 °C, 101.325 kPa)|
|Liquid density||at b.p.: 1.505 g·cm−34|
|Triple point||53.48 K, 90 kPa2|
|Critical point||144.41 K, 5.1724 MPa2|
|Heat of vaporization||6.51 kJ·mol−13|
|Molar heat capacity||Cp: 31 J·mol−1·K−14 (at 21.1 °C)
Cv: 23 J·mol−1·K−14 (at 21.1 °C)
|Oxidation states||−1 (oxidizes oxygen)|
|Electronegativity||3.98 (Pauling scale)1|
|Ionization energies||1st: 1681 kJ·mol−1
2nd: 3374 kJ·mol−1
3rd: 6147 kJ·mol−1
|Covalent radius||64 pm6|
|Van der Waals radius||135 pm7|
|Crystal structure||alpha: base-centered monoclinic8
|Thermal conductivity||0.02591 W·m−1·K−19|
|Magnetic ordering||diamagnetic (−1.2×10−4)1011|
|Naming||after the mineral fluorite, itself named after Latin fluo (to flow, in smelting)|
|Discovery||André-Marie Ampère (1810)|
|First isolation||Henri Moissan1 (June 26, 1886)|
|Named by||Humphry Davy|
|Most stable isotopes|
|Main article: Isotopes of fluorine|
Fluorine is a chemical element with the symbol F and atomic number 9. It is the lightest halogen and exists as a highly toxic pale yellow diatomic gas at standard conditions. As the most electronegative element, it is extremely reactive: almost all other elements, including some noble gases, form compounds with fluorine.
Among the elements, fluorine ranks 24th in universal abundance and 13th in terrestrial abundance. Fluorite, the primary mineral source of fluorine, was first described in 1529; as it was added to metal ores to lower their melting points for smelting, the Latin verb fluo meaning "flow" became associated with it. Proposed as an element in 1810, fluorine proved difficult and dangerous to separate from its compounds, and several early experimenters died or sustained injuries from their attempts. Only in 1886 did French chemist Henri Moissan isolate elemental fluorine using low-temperature electrolysis, a process still employed for modern production. Industrial synthesis of fluorine gas for uranium enrichment, its largest application, began during the Manhattan Project in World War II.
Due to the expense of refining pure fluorine, most commercial applications of the element involve the use of its compounds, with about half of mined fluorite used in steelmaking. The rest is converted into corrosive hydrogen fluoride en route to various organic fluorides, or into cryolite which plays a key role in aluminium refining. Organic fluorides have very high chemical and thermal stability; their major uses are as refrigerants, electrical insulation and cookware, the last as PTFE (Teflon). Pharmaceuticals such as atorvastatin and fluoxetine also contain fluorine, and the fluoride ion inhibits dental cavities, and so finds use in toothpaste and water fluoridation. Global fluorochemical sales amount to over US$15 billion a year.
Fluorocarbon gases are generally greenhouse gases with global-warming potentials 100 to 20,000 times that of carbon dioxide. Organofluorine compounds, with an uncertain potential impact on health, persist in the environment due to the strength of the carbon–fluorine bond. Fluorine has no known metabolic role in mammals; a few plants synthesize organofluorine poisons to deter herbivores.
- 1 Characteristics
- 2 Occurrence
- 3 History
- 4 Compounds
- 5 Production
- 6 Industrial applications
- 7 Medicinal applications
- 8 Biological role
- 9 Toxicity
- 10 Environmental concerns
- 11 See also
- 12 Notes
- 13 Sources
Fluorine atoms have nine electrons, one fewer than neon, and electron configuration 1s22s22p5: two electrons in a filled inner shell and seven in an outer shell requiring one more to be filled. The outer electrons are ineffective at nuclear shielding, and experience a high effective nuclear charge of 9 − 2 = 7; this affects the atom's physical properties.1
Fluorine's first ionization energy is third-highest among all elements, behind helium and neon,13 which complicates the removal of electrons from neutral fluorine atoms. It also has a high electron affinity, second only to chlorine,14 and tends to capture an electron to become isoelectronic with the noble gas neon;1 it has the highest electronegativity of any element.15 Fluorine atoms have a small covalent radius of around 60 picometers, similar to those of its period neighbors oxygen and neon.1617note 1
The bond energy of difluorine is much lower than that of either Cl
2 or Br
2 and similar to the easily cleaved peroxide bond; this, along with high electronegativity, accounts for fluorine's easy dissociation, high reactivity and strong bonds to non-fluorine atoms.1819 Conversely, bonds to other atoms are very strong because of fluorine's high electronegativity. Unreactive substances like powdered steel, glass fragments, and asbestos fibers react quickly with cold fluorine gas; wood and water spontaneously combust under a fluorine jet.320
|Bright flames during fluorine reactions|
|Fluorine reacting with caesium|
Reactions of elemental fluorine with metals require varying conditions. Alkali metals cause explosions and alkaline earth metals display vigorous activity in bulk; to prevent passivation from the formation of metal fluoride layers most other metals such as aluminium and iron must be powdered,18 and noble metals require pure fluorine gas at 300–450 °C (575–850 °F).21 Some solid nonmetals (sulfur, phosphorus) react vigorously in liquid air temperature fluorine.22 Hydrogen sulfide22 and sulfur dioxide23 combine readily with fluorine, the latter sometimes explosively; sulfuric acid exhibits much less activity, requiring elevated temperatures.24
Hydrogen, like some of the alkali metals, reacts explosively with fluorine.25 Carbon, as lamp black, reacts at room temperature to yield fluoromethane. Graphite combines with fluorine above 400 °C (750 °F) to produce non-stoichiometric carbon monofluoride; higher temperatures generate gaseous fluorocarbons, sometimes with explosions.26 Carbon dioxide and carbon monoxide react at or just above room temperature,27 whereas paraffins and other organic chemicals generate strong reactions:28 even fully substituted haloalkanes such as carbon tetrachloride, normally incombustible, may explode.29 Although nitrogen trifluoride is stable, nitrogen requires an electric discharge at elevated temperatures for reaction due to its very strong triple bond;30 ammonia may react explosively.3132 Oxygen does not combine with fluorine under ambient conditions, but can be made to using electric discharge at low temperatures and pressures; the products tend to disintegrate into their constituent elements when heated.333435 Heavier halogens36 and radon37 react readily with fluorine; the lighter noble gases xenon and krypton require special conditions.38
At room temperature, fluorine is a gas of diatomic molecules,3 pale yellow when pure (but sometimes described as yellow-green).39 It has a characteristic pungent odor detectable at 20 ppb.40 Fluorine condenses into a bright yellow liquid at −188 °C (−306 °F), a similar transition temperature to those of oxygen and nitrogen.41
Fluorine has two solid forms, α- and β-fluorine. The latter crystallizes at −220 °C (−364 °F) and is transparent and soft, with the same disordered cubic structure of freshly crystallized solid oxygen,41note 2 unlike the orthorhombic systems of other solid halogens.845 Further cooling to −228 °C (−378 °F) induces a phase transition into opaque and hard α-fluorine, which has a monoclinic structure with dense, angled layers of molecules. The transition from β- to α-fluorine is more exothermic than the condensation of fluorine, and can be violent.845note 3
Only one isotope of fluorine occurs naturally to any significant extent, the stable 19
F that has ten neutrons.46 It has a high magnetogyric rationote 4 and exceptional sensitivity to magnetic fields; because it is also the only stable isotope, it is used in magnetic resonance imaging.48 Seventeen radioisotopes with mass numbers from 14 to 31 have been synthesized, of which 18
F is the most stable with a half-life of 109.77 minutes. Other radioisotopes have half-lives less than 70 seconds; most decay in less than half a second.49 The isotopes 17
F and 18
F undergo β+ decay, lighter isotopes decay via electron capture, and those heavier than 19
F undergo β− decay or neutron emission.49 One metastable isomer of fluorine is known, 18m
F, with a half-life of 234 nanoseconds.50
Among the lighter elements, fluorine's abundance value of 400 ppb (parts per billion) – 24th among elements in the universe – is exceptional: other elements from carbon to magnesium are twenty or more times as common.52 This is because stellar nucleosynthesis processes bypass fluorine, and any fluorine atoms otherwise created have high nuclear cross sections, allowing further fusion with hydrogen or helium to generate oxygen or neon respectively.5253
- during type II supernovae, bombardment of neon atoms by neutrinos could transmute them to fluorine;
- the solar wind of Wolf–Rayet stars could blow fluorine away from any hydrogen or helium atoms; or
- fluorine is borne out on convection currents arising from fusion in asymptotic giant branch stars.
Fluorine is the thirteenth most common element in Earth's crust at 600–700 ppm (parts per million) by mass.55 Elemental fluorine in Earth's atmosphere would easily react with rocks, precluding its natural occurrence;5657 it is found only in combined mineral forms, of which fluorite, fluorapatite and cryolite are the most industrially significant.5558 Fluorite or fluorspar (CaF
2), colorful and abundant worldwide, is fluorine's main source; China and Mexico are the major suppliers. The U.S. led extraction in the early 20th century but ceased mining in 1995.5859606162 Although fluorapatite (Ca5(PO4)3F) contains most of the world's fluorine, its low mass fraction of 3.5% means that most of it is used as a phosphate. In the U.S. small quantities of fluorine compounds are obtained via fluorosilicic acid, a phosphate industry byproduct.58 Cryolite (Na
6), once used directly in aluminium production, is the rarest and most concentrated of these three minerals. The main commercial mine on Greenland's west coast closed in 1987, and most cryolite is now synthesized.58
|Major fluorine-containing minerals|
Other minerals such as topaz contain fluorine. Fluorides, unlike other halides, are insoluble and do not occur in commercially favorable concentrations in saline waters.58 Trace quantities of organofluorines of uncertain origin have been detected in volcanic eruptions and geothermal springs.63 The existence of gaseous fluorine in crystals, suggested by the smell of crushed antozonite, is contentious;6465 a 2012 study reported the presence of 0.04% F
2 by weight in antozonite, attributing these inclusions to radiation from the presence of tiny amounts of uranium.65
In 1529, Georgius Agricola described fluorite as an additive used to lower the melting point of metals during smelting.6667note 5 He penned the Latin word fluorés (fluo, flow) for fluorite rocks. The name later evolved into fluorspar (still commonly used) and then fluorite.597172 The composition of fluorite was later determined to be calcium difluoride.73
Hydrofluoric acid was used in glass etching from 1720 onwards.note 6 Andreas Sigismund Marggraf first characterized it in 1764 when he heated fluorite with sulfuric acid, and the resulting solution corroded its glass container.7576 Swedish chemist Carl Wilhelm Scheele repeated the experiment in 1771, and named the acidic product fluss-spats-syran (fluorspar acid).7677 In 1810, the French physicist André-Marie Ampère suggested that hydrogen and an element analogous to chlorine constituted hydrofluoric acid.78 Sir Humphry Davy proposed that this then-unknown substance be named fluorine from fluoric acid and the -ine suffix of other halogens. This word, with modifications, is used in most European languages; Greek, Russian, and some others (following Ampère's suggestion) use the name ftor or derivatives, from the Greek φθόριος (phthorios, destructive) .7980 The New Latin name fluorum gave the element its current symbol F; Fl was used in early papers.81note 7
Initial studies on fluorine were so dangerous that several 19th century experimenters were deemed "fluorine martyrs" after misfortunes with hydrofluoric acid.note 8 Isolation of elemental fluorine was hindered by the extreme corrosiveness of both it and hydrogen fluoride, as well as the lack of a simple and suitable electrolyte.7382 Edmond Frémy postulated that electrolysis of pure hydrofluoric acid to generate fluorine was feasible and devised a method to produce anhydrous samples from acidified potassium bifluoride; instead, he discovered that the resulting (dry) hydrogen floride did not conduct.738283 Frémy's former student Henri Moissan persevered, and after much trial and error found that a mixture of potassium bifluoride and dry hydrogen fluoride was a conductor, enabling electrolysis. To prevent rapid corrosion of the platinum in his electrochemical cells, he cooled the reaction to extremely low temperatures in a special bath and forged cells from a more resistant mixture of platinum and iridium, and used fluorite stoppers.8284 In 1886, after 74 years of effort, Moissan isolated elemental fluorine.8385
[I]n recognition of the great services rendered by him in his investigation and isolation of the element fluorine ... The whole world has admired the great experimental skill with which you have studied that savage beast among the elements.note 9
|1887 drawing of Moissan's apparatus||Nobel Prize photo of Moissan|
The Frigidaire division of General Motors experimented with chlorofluorocarbon refrigerants in the late 1920s, and Kinetic Chemicals was formed as a joint venture between GM and DuPont in 1930 hoping to market Freon-12 (CCl
2) as one such refrigerant. It replaced earlier and more toxic compounds, increased demand for kitchen refrigerators, and became profitable; by 1949 DuPont had bought out Kinetic and marketed several other Freon compounds.76878889 Polytetrafluoroethylene (Teflon) was serendipitously discovered in 1938 by Roy J. Plunkett while working on refrigerants at Kinetic, and its superlative chemical and thermal resistance lent it to accelerated commercialization and mass production by 1941.768788
Elemental fluorine's large-scale synthesis began during World War II. Germany used high-temperature electrolysis to make tons of the planned incendiary chlorine trifluoride90 and the Manhattan Project used huge quantities to produce uranium hexafluoride for uranium enrichment. Since UF
6 is as corrosive as fluorine, gaseous diffusion plants required special materials: nickel for membranes, fluoropolymers for seals, and liquid fluorocarbons as coolants and lubricants. This burgeoning nuclear industry later drove post-war fluorochemical development.91
Fluorine has a rich chemistry, encompassing organic and inorganic domains. It combines with metals, nonmetals, metalloids, and most noble gases,92 and usually assumes an oxidation state of −1.note 10 Fluorine's high electron affinity results in a preference for ionic bonding; when it forms covalent bonds these are polar and almost always single.9697note 11
Alkali metals form ionic and highly soluble monofluorides; these have the cubic arrangement of sodium chloride and analogous chlorides.9899 Alkaline earth difluorides possess strong ionic bonds but are insoluble81 save for beryllium difluoride, which also exhibits some covalent character and has a quartz-like structure.100 Rare earth elements and many other metals form mostly ionic trifluorides.101102103
Covalent bonding first comes to prominence in the tetrafluorides: those of zirconium, hafnium104105 and several actinides106 are ionic with high melting points,107note 12 while those of titanium,110 vanadium,111 and niobium are polymeric,112 melting or decomposing at no more than 350 °C (660 °F).113 Pentafluorides continue this trend with their linear polymers and oligomeric complexes.114115116 Thirteen metal hexafluorides are known,note 13 all octahedral, and are mostly volatile solids but for liquid MoF
6 and ReF
6, and gaseous WF
6.117118119 Rhenium heptafluoride, the only characterized metal heptafluoride, is a low-melting molecular solid with pentagonal bipyramidal molecular geometry.120 Metal fluorides with more fluorine atoms are particularly reactive.121
|Structural progression of metal fluorides|
|Sodium fluoride, ionic||Bismuth pentafluoride, polymeric||Rhenium heptafluoride, molecular|
Hydrogen and fluorine combine to yield hydrogen fluoride, in which discrete molecules form clusters via hydrogen bonding. Hydrogen fluoride thus behaves more like water than hydrogen chloride.122123124 It boils at a much higher temperature than heavier hydrogen halides and unlike them is fully miscible with water.125 Hydrofluoric acid – aqueous hydrogen fluoride – is a weak acid unlike the other strong hydrohalic acids,126note 14 but is corrosive enough to attack glass.128
- Metalloids are included in this section
Boron trifluoride is planar and possesses an incomplete octet. It functions as a Lewis acid and combines with Lewis bases like ammonia to form adducts.131 Carbon tetrafluoride is tetrahedral and inert;note 15 its group analogues, silicon and germanium tetrafluoride, are also tetrahedral132 but behave as Lewis acids.133134 The pnictogens form trifluorides that increase in reactivity and basicity with higher molecular weight, although nitrogen trifluoride resists hydrolysis and is not basic.135 Phosphorus, arsenic, and antimony form pentafluorides more reactive than their respective trifluorides, with antimony pentafluoride the strongest neutral Lewis acid known.114136137
Chalcogens have diverse fluorides: unstable difluorides have been reported for oxygen (the only known compound with oxygen in an oxidation state of +2), sulfur, and selenium; tetrafluorides and hexafluorides exist for sulfur, selenium, and tellurium. The latter are stabilized by more fluorine atoms and lighter central atoms, so sulfur hexafluoride is especially inert.138139 Chlorine, bromine, and iodine can each form mono-, tri-, and pentafluorides, but only iodine heptafluoride has been characterized among possible interhalogen heptafluorides.140 Many of them are powerful sources of fluorine atoms, and chlorine trifluoride's industrial applications require precautions similar to those applying to fluorine.141142
Noble gases, having complete electron shells, defied reaction with other elements until 1962 when Neil Bartlett reported synthesis of xenon hexafluoroplatinate;144 xenon difluoride, tetrafluoride, hexafluoride, and multiple oxyfluorides have been isolated since then.145 Among other noble gases, krypton forms a difluoride,146 and radon and fluorine generate a solid suspected to be radon difluoride.147148 Binary fluorides of lighter noble gases are exceptionally unstable: argon and hydrogen fluoride combine under extreme conditions to give argon fluorohydride.38 Helium and neon have no long-lived fluorides,149 and no neon fluoride has ever been observed;150 helium fluorohydride has been detected for milliseconds at high pressures and low temperatures.149
The carbon–fluorine bond is organic chemistry's strongest,152 and gives stability to organofluorines.153 It is almost non-existent in nature, but is used in artificial compounds. Research in this area is usually driven by commercial applications;154 the compounds involved are diverse and reflect the complexity inherent in organic chemistry.87
The substitution of hydrogen atoms in an alkane by progressively more fluorine atoms gradually alters several properties: melting and boiling points are lowered, density increases, solubility in hydrocarbons decreases and overall stability increases. Perfluorocarbons,note 16 in which all hydrogen atoms are substituted, are insoluble in most organic solvents, reacting at ambient conditions only with sodium in liquid ammonia.155
The term perfluorinated compound is used for what would otherwise be a perfluorocarbon if not for the presence of a functional group,156note 17 often a carboxylic acid. These compounds share many properties with perfluorocarbons such as stability and hydrophobicity,158 while the functional group augments their reactivity, enabling them to adhere to surfaces or act as surfactants;159 Fluorosurfactants, in particular, can lower the surface tension of water more than their hydrocarbon-based analogues. Fluorotelomers, which have some unfluorinated carbon atoms near the functional group, are also regarded as perfluorinated.158
Polymers exhibit the same stability increases afforded by fluorine substitution (for hydrogen) in discrete molecules; their melting points generally increase too.160 Polytetrafluoroethylene (PTFE), the simplest fluoropolymer and perfluoro analogue of polyethylene with structural unit –CF
2–, demonstrates this change as expected, but its very high melting point makes it difficult to mold.161 Various PTFE derivatives are less temperature-tolerant but easier to mold: fluorinated ethylene propylene replaces some fluorine atoms with trifluoromethyl groups, perfluoroalkoxy alkanes do the same with trifluoromethoxy groups,161 and Nafion contains perfluoroether side chains capped with sulfonic acid groups.162163 Other fluoropolymers retain some hydrogen atoms; polyvinylidene fluoride has half the fluorine atoms of PTFE and polyvinyl fluoride has a quarter, but both behave much like perfluorinated polymers.164
Moissan's method is used to produce industrial quantities of fluorine, via the electrolysis of a potassium fluoride/hydrogen fluoride mixture: hydrogen and fluoride ions are reduced and oxidized at a steel container cathode and a carbon block anode, under 8–12 volts, to generate hydrogen and fluorine gas respectively.60165 Temperatures are elevated, KF•2HF melting at 70 °C (158 °F) and being electrolyzed at 70–130 °C (158–266 °F). KF, which acts as catalyst, is essential since pure HF cannot be electrolyzed.76166167 Fluorine can be stored in steel cylinders that have passivated interiors, at temperatures below 200 °C (392 °F); otherwise nickel can be used.76168 Regulator valves and pipework are made of nickel, the latter possibly using Monel instead.169 Frequent passivation, along with the strict exclusion of water and greases, must be undertaken. In the laboratory, glassware may carry fluorine gas under low pressure and anhydrous conditions;169 some sources instead recommend nickel-Monel-PTFE systems.170
While preparing for a 1986 conference to celebrate the centennial of Moissan's achievement, Karl O. Christe reasoned that chemical fluorine generation should be feasible since some metal fluoride anions have no stable neutral counterparts; their acidification potentially triggers oxidation instead. He devised a method which evolves fluorine at high yield and atmospheric pressure:171
- 2 KMnO4 + 2 KF + 10 HF + 3 H2O2 → 2 K2MnF6 + 8 H2O + 3 O2↑
- 2 K2MnF6 + 4 SbF5 → 4 KSbF6 + 2 MnF3 + F2↑
Christe later commented that the reactants "had been known for more than 100 years and even Moissan could have come up with this scheme."172 As late as 2008, some references still asserted that fluorine was too reactive for any chemical isolation.173
Fluorite mining, which supplies most global fluorine, peaked in 1989 when 5.6 million metric tons of ore were extracted. Chlorofluorocarbon restrictions lowered this to 3.6 million tons in 1994; production has since been increasing. Around 4.5 million tons of ore and revenue of US$550 million were generated in 2003; later reports estimated 2011 global fluorochemical sales at $15 billion and predicted 2016–18 production figures of 3.5 to 5.9 million tons, and revenue of at least $20 billion.76174175176177 Froth flotation separates mined fluorite into two main metallurgical grades of equal proportion: 60–85% pure metspar is almost all used in iron smelting whereas 97%+ pure acidspar is mainly converted to the key industrial intermediate hydrogen fluoride.6076178
At least 17,000 metric tons of fluorine are produced each year. It costs only $5–8 per kilogram as uranium or sulfur hexafluoride, but handling challenges multiply its price as an element, and most processes that use the latter in large amounts employ in situ generation under vertical integration.179
The largest application of fluorine, consuming up to 7,000 metric tons annually, is in the preparation of UF
6 for the nuclear fuel cycle. Fluorine is used to fluorinate uranium tetrafluoride, itself formed from uranium dioxide and hydrofluoric acid.179 Fluorine is monoisotopic, so any mass differences between UF
6 molecules are due to the presence of 235
U or 238
U, enabling uranium enrichment via gaseous diffusion or gas centrifuge.360 About 6,000 metric tons per year go into producing the inert dielectric SF
6 for high-voltage transformers and circuit breakers, eliminating the need for hazardous polychlorinated biphenyls associated with oil-filled devices.180 Several fluorine compounds are used in electronics: rhenium and tungsten hexafluoride in chemical vapor deposition, tetrafluoromethane in plasma etching181182183 and nitrogen trifluoride in cleaning equipment.60 Fluorine is also used in the synthesis of organic fluorides, but its reactivity often necessitates conversion first to the gentler ClF
3, or IF
5, which together allow calibrated fluorination. Fluorinated pharmaceuticals use sulfur tetrafluoride instead.60
As with other iron alloys, around 3 kg (6.5 lb) metspar is added to each metric ton of steel; the fluoride ions lower its melting point and viscosity.60184 Alongside its role as an additive in materials like enamels and welding rod coats, most acidspar is reacted with sulfuric acid to form hydrofluoric acid, which is used in steel pickling, glass etching and alkane cracking.60 One-third of HF goes into synthesizing cryolite and aluminium trifluoride, both fluxes in the Hall–Héroult process for aluminium extraction; replenishment is necessitated by their occasional reactions with the smelting apparatus. Each metric ton of aluminium requires about 23 kg (51 lb) of flux.60185 Fluorosilicates consume the second largest portion, with sodium fluorosilicate used in water fluoridation and laundry effluent treatment, and as an intermediate en route to cryolite and silicon tetrafluoride.186 Other important inorganic fluorides include those of cobalt, nickel, and ammonium.6099187
Organofluorides consume over 20% of mined fluorite and over 40% of hydrofluoric acid, with refrigerant gases dominating and fluoropolymers increasing their market share.60188 Surfactants are a minor application but generate over $1 billion in annual revenue.189 Due to the danger from direct hydrocarbon–fluorine reactions above −150 °C (−240 °F), industrial fluorocarbon production is indirect, mostly through halogen exchange reactions such as Swarts fluorination, in which chlorocarbon chlorines are substituted for fluorines by hydrogen fluoride under catalysts. Electrochemical fluorination subjects hydrocarbons to electrolysis in hydrogen fluoride, and the Fowler process treats them with solid fluorine carriers like cobalt trifluoride.87190
Halogenated refrigerants, termed Freons in informal contexts,note 18 are identified by R-numbers that denote the amount of fluorine, chlorine, carbon, and hydrogen present.60191 Chlorofluorocarbons (CFCs) like R-11, R-12, and R-114 once dominated organofluorines, peaking in production in the 1980s. Used for air conditioning systems, propellants and solvents, their production was below one-tenth of this peak by the early 2000s, after widespread international prohibition.60 Hydrochlorofluorocarbons (HCFCs) and hydrofluorocarbons (HFCs) were designed as replacements; their synthesis consumes more than 90% of the fluorine in the organic industry. Important HCFCs include R-22, chlorodifluoromethane, and R-141b. The main HFC is R-134a60 with HFO-1234yf coming to prominence owing to its global warming potential of less than 1% that of HFC-134a.192
About 180,000 metric tons of fluoropolymers were produced in 2006 and 2007, generating over $3.5 billion revenue per year.193 The global market was estimated at just under $6 billion in 2011 and was predicted to grow by 6.5% per year up to 2016.194 Fluoropolymers can only be formed by polymerizing free radicals.160
Polytetrafluoroethylene (PTFE), sometimes called by its DuPont name Teflon,195 represents 60–80% by mass of the world's fluoropolymer production.193 The largest application is in electrical insulation since PTFE is an excellent dielectric. It is also used in the chemical industry where corrosion resistance is needed, in coating pipes, tubing, and gaskets. Another major use is in PFTE-coated fiberglass cloth for stadium roofs. The major consumer application is for non-stick cookware.195 Jerked PTFE film becomes expanded PTFE (ePTFE), a fine-pored membrane sometimes referred to by the brand name Gore-Tex and used for rainwear, protective apparel, and filters; ePTFE fibers may be made into seals and dust filters.195 Other fluoropolymers, including fluorinated ethylene propylene, mimic PTFE's properties and can substitute for it; they are more moldable, but also more costly and have lower thermal stability. Films from two different fluoropolymers replace glass in solar cells.195196
The chemically resistant (but expensive) fluorinated ionomers are used as electrochemical cell membranes, of which the first and most prominent example is Nafion. Developed in the 1960s, it was initially deployed as fuel cell material in spacecraft and then replaced mercury-based chloralkali process cells. Recently, the fuel cell application has reemerged with efforts to install proton exchange membrane fuel cells into automobiles.197198199 Fluoroelastomers such as Viton are crosslinked fluoropolymer mixtures mainly used in O-rings;195 perfluorobutane (C4F10) is used as a fire-extinguishing agent.200
Fluorosurfactants are small organofluorine molecules used for repelling water and stains. Although expensive (comparable to pharmaceuticals at $200–2000 per kilogram), they yielded over $1 billion in annual revenues by 2006; Scotchgard alone generated over $300 million in 2000.189201202 Fluorosurfactants are a minority in the overall surfactant market, most of which is taken up by much cheaper hydrocarbon-based products. Applications in paints are burdened by compounding costs; this use was valued at only $100 million in 2006.189
About 30% of agrichemicals contain fluorine,203 most of them herbicides and fungicides with a few crop regulators. Fluorine substitution, usually of a single atom or at most a trifluoromethyl group, is a robust modification with effects analogous to fluorinated pharmaceuticals: increased biological stay time, membrane crossing, and altering of molecular recognition.204 Trifluralin is a prominent example, with large-scale use in the U.S. as a weedkiller,204205 but it is a suspected carcinogen and has been banned in many European countries.206 Sodium monofluoroacetate (1080) is a mammalian poison in which two acetic acid hydrogens are replaced with fluorine and sodium; it disrupts cell metabolism by replacing acetate in the citric acid cycle. First synthesized in the late 19th century, it was recognized as an insecticide in the early 20th, and was later deployed in its current use. New Zealand, the largest consumer of 1080, uses it to protect kiwis from the invasive Australian common brushtail possum.207 Europe and the U.S. have banned 1080.208209note 19
Population studies from the mid-20th century onwards show topical fluoride reduces dental caries. This was first attributed to the conversion of tooth enamel hydroxyapatite into the more durable fluorapatite, but studies on pre-fluoridated teeth refuted this hypothesis, and current theories involve fluoride aiding enamel growth in small caries.210 After studies of children in areas where fluoride was naturally present in drinking water, controlled public water supply fluoridation to fight tooth decay211 began in the 1940s and is now applied to water supplying 6 percent of the global population, including two-thirds of Americans.212213 Reviews of the scholarly literature in 2000 and 2007 associated water fluoridation with a significant reduction of tooth decay in children.214 Despite public endorsement, and the best available evidence showing no adverse effects other than mostly benign dental fluorosis,215 opposition to water fluoridation on ethical and safety grounds213 still exists.216 The benefits of fluoridation have lessened, possibly due to other fluoride sources, but are still measurable in low-income groups.217 Sodium monofluorophosphate and sometimes sodium or tin(II) fluoride are often found in fluoride toothpastes, first introduced in the U.S. in 1955 and now ubiquitous in developed countries, alongside fluoridated mouthwashes, gels, foams, and varnishes.217218
Twenty percent of modern pharmaceuticals contain fluorine.220 One of these, the cholesterol-reducer Atorvastatin (Lipitor), made more revenue than any other drug until it became generic in 2011.221 The combination asthma prescription Seretide, a top-ten revenue drug in the mid-2000s, contains two active ingredients, one of which – fluticasone – is fluorinated.222 Many drugs are fluorinated to delay inactivation and lengthen dosage periods because the carbon–fluorine bond is very stable.223 Fluorination also increases lipophilicity because the bond is more hydrophobic than the carbon–hydrogen bond, and this often helps in cell membrane penetration and hence bioavailability.222
Tricyclics and other pre-1980s antidepressants had several side effects due to their non-selective interference with neurotransmitters other than the serotonin target; the fluorinated fluoxetine was selective and one of the first to avoid this problem. Many current antidepressants receive this same treatment, including the selective serotonin reuptake inhibitors: citalopram, its isomer escitalopram, and fluvoxamine and paroxetine.224225 Quinolones are artificial broad-spectrum antibiotics that are often fluorinated to enhance their effects. These include ciprofloxacin and levofloxacin.226227228229 Fluorine also finds use in steroids:230 fludrocortisone is a blood pressure-raising mineralocorticoid, and triamcinolone and dexamethasone are strong glucocorticoids.231 The majority of inhaled anesthetics are heavily fluorinated; the prototype halothane is much more inert and potent than its contemporaries. Later compounds such as the fluorinated ethers sevoflurane and desflurane are better than halothane and are almost insoluble in blood, allowing faster waking times.232233
Fluorine-18 is often found in radioactive tracers for positron emission tomography, as its half-life of almost two hours is long enough to allow for its transport from production facilities to imaging centers.234 The most common tracer is fluorodeoxyglucose234 which, after intravenous injection, is taken up by glucose-requiring tissues such as the brain and most malignant tumors;235 computer-assisted tomography can then be used for detailed imaging.236
Liquid fluorocarbons can hold large volumes of oxygen or carbon dioxide, more so than blood, and have attracted attention for their possible uses in artificial blood and in liquid breathing.237 Because fluorocarbons do not normally mix with water, they must be mixed into emulsions (small droplets of perfluorocarbon suspended in water) to be used as blood.238239 One such product, Oxycyte, has been through initial clinical trials.240 These substances can aid endurance athletes and are banned from sports; one cyclist's near death in 1998 prompted an investigation into their abuse.241242 Applications of pure perfluorocarbon liquid breathing (which uses pure perfluorocarbon liquid, not a water emulsion) include assisting burn victims and premature babies with deficient lungs. Partial and complete lung filling have been considered, though only the former has had any significant tests in humans.243 An Alliance Pharmaceuticals effort reached clinical trials but was abandoned because the results were not better than normal therapies.244
Fluorine is not essential for humans or other mammals; small amounts may be beneficial for bone strength, but this has not been definitively established. As there are many environmental sources of trace fluorine, the possibility of a fluorine deficiency could apply only to artificial diets.245246 Natural organofluorines have been found in microorganisms and plants63 but not animals.247 The most common is fluoroacetate, which is used as a defense against herbivores by at least 40 plants in Africa, Australia and Brazil.208 Other examples include terminally fluorinated fatty acids, fluoroacetone, and 2-fluorocitrate.247 An enzyme that binds fluorine to carbon – Adenosyl-fluoride synthase – was discovered in bacteria in 2002.248
Elemental fluorine is highly toxic to living organisms. Its effects in humans start at concentrations lower than hydrogen cyanide's 50 ppm250 and are similar to those of chlorine:251 significant irritation of the eyes and respiratory system as well as liver and kidney damage occur above 25 ppm. Eyes and noses are seriously damaged at 100 ppm,252 and inhalation of 1,000 ppm fluorine will cause death in minutes,253 compared to 270 ppm for hydrogen cyanide.254
Hydrofluoric acid is a contact poison with greater hazards than many strong acids like sulfuric acid even though it is weak: it remains neutral in aqueous solution and thus penetrates tissue faster, whether through inhalation, ingestion or the skin, and at least nine U.S. workers died in such accidents from 1984 to 1994. It reacts with calcium and magnesium in the blood leading to hypocalcemia and possible death through cardiac arrhythmia.256 Insoluble calcium fluoride formation triggers strong pain257 and burns larger than 160 cm2 (25 in2) can cause serious systemic toxicity.258
Exposure may not be evident for eight hours for 50% HF, rising to 24 hours for lower concentrations, and a burn may initially be painless as hydrogen fluoride affects nerve function. If skin has been exposed to HF, damage can be reduced by rinsing it under a jet of water for 10–15 minutes and removing contaminated clothing.259 Calcium gluconate is often applied next, providing calcium ions to bind with fluoride; skin burns can be treated with 2.5% calcium gluconate gel or special rinsing solutions.260261262 Hydrofluoric acid absorption requires further medical treatment; calcium gluconate may be injected or administered intravenously. Using calcium chloride – a common laboratory reagent – in lieu of calcium gluconate is contraindicated, and may lead to severe complications. Excision or amputation of affected parts may be required.258263
Soluble fluorides are moderately toxic: 5–10 g sodium fluoride, or 32–64 mg fluoride ions per kilogram of body mass, represents a lethal dose for adults.264 One-fifth of the lethal dose can cause adverse health effects,265 and chronic excess consumption may lead to skeletal fluorosis, which affects millions in Asia and Africa.265266 Ingested fluoride forms hydrofluoric acid in the stomach which is easily absorbed by the intestines, where it crosses cell membranes, binds with calcium and interferes with various enzymes, before urinary excretion. Exposure limits are determined by urine testing of the body's ability to clear fluoride ions.265267
Historically, most cases of fluoride poisoning have been caused by accidental ingestion of insecticides containing inorganic fluorides.268 Most current calls to poison control centers for possible fluoride poisoning come from the ingestion of fluoride-containing toothpaste.265 Malfunctioning water fluoridation equipment is another cause: one incident in Alaska affected almost 300 people and killed one person.269 Dangers from toothpaste are aggravated for small children, and the Centers for Disease Control and Prevention recommends supervising children below six brushing their teeth so that they do not swallow toothpaste.270 One regional study examined a year of pre-teen fluoride poisoning reports totaling 87 cases, including one death from ingesting insecticide. Most had no symptoms, but about 30% had stomach pains.268 A larger study across the U.S. showed similar findings: 80% of cases involved children under six, and there were few serious cases.271
The Montreal Protocol, signed in 1987, set strict regulations on chlorofluorocarbons (CFCs) and bromofluorocarbons due to their ozone damaging potential (ODP). The high stability which suited them to their original applications also meant that they were not decomposing until they reached higher altitudes, where liberated chlorine and bromine atoms attacked ozone molecules.273 Even with the ban, and early indications of its efficiacy, predictions warned that several generations would pass before full recovery.274275 With one-tenth the ODP of CFCs, hydrochlorofluorocarbons (HCFCs) are the current replacements,276 and are themselves scheduled for substitution by 2030–2040 by hydrofluorocarbons (HFCs) with no chlorine and zero ODP.277 In 2007 this date was brought forward to 2020 for developed countries;278 the Environmental Protection Agency had already prohibited one HCFC's production and capped those of two others in 2003.277 Fluorocarbon gases are generally greenhouse gases with global-warming potentials (GWPs) of about 100 to 10,000; sulfur hexafluoride has a value of around 20,000.279 An outlier is HFO-1234yf which has attracted global demand due to its GWP of 4 compared to 1,430 for the current refrigerant standard HFC-134a.192
Organofluorines exhibit biopersistence due to the strength of the carbon–fluorine bond. Perfluoroalkyl acids (PFAAs), which are sparingly water-soluble owing to their acidic functional groups, are noted persistent organic pollutants;281 perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) are most often researched.282283284 PFAAs have been found in trace quantities worldwide from polar bears to humans, with PFOS and PFOA known to reside in breast milk and the blood of newborn babies. A 2013 review showed a slight correlation between groundwater and soil PFAA levels and human activity; there was no clear pattern of one chemical dominating, and higher amounts of PFOS were correlated to higher amounts of PFOA.282283285 In the body, PFAAs bind to proteins such as serum albumin; they tend to concentrate within humans in the liver and blood before excretion through the kidneys. Dwell time in the body varies greatly by species, with half-lives of days in rodents, and years in humans.282283286 High doses of PFOS and PFOA cause cancer and death in newborn rodents but human studies have not established an effect at current exposure levels.282283286 Other fluorochemicals also persist, like antibiotics and antidepressants in treated sewage,287 and agrichemicals in farmland runoff and nearby rivers,288 since they do not biodegrade easily.287
- Fluoride selective electrode, which measures fluoride concentration
- Fluorine absorption dating
- Fluorous chemistry, a process to separate reagents from organic solvents
- Krypton and argon fluoride laser
- Sources disagree on the radii of oxygen, fluorine, and neon atoms. Precise comparison is thus impossible.
- α-Fluorine has a regular pattern of molecules and is a crystalline solid, but its molecules do not have a specific orientation. β-Fluorine's molecules have fixed location (reminiscent of the atom locations in the A15 phases) and minimal rotational uncertainty. For further detail on α-fluorine, see the 1970 structure by Pauling.42 For further detail on the concept of disorder in crystals, see the referenced general reviews.4344
- A loud click is heard. Samples may shatter and sample windows blow out.
- The ratio of the angular momentum to magnetic moment is called the gyromagnetic ratio. "Certain nuclei can for many purposes be thought of as spinning round an axis like the Earth or like a top. In general the spin endows them with angular momentum and with a magnetic moment; the first because of their mass, the second because all or part of their electric charge may be rotating with the mass."47
- Basilius Valentinus supposedly described fluorite in the late 15th century, but because his writings were uncovered 200 years later, this work's veracity is doubtful.686970
- Or perhaps from as early as 1670 onwards; Partington74 and Weeks73 give differing accounts.
- Fl, since 2012, is used for flerovium.
- Davy, Gay-Lussac, Thénard, and the Irish chemists Thomas and George Knox were injured. Belgian chemist Paulin Louyet and French chemist Jérôme Nicklès died. Moissan also experienced serious hydrogen fluoride poisoning.7382
- Also honored was his invention of the electric arc furnace.
- Fluorine in F
2 is defined to have oxidation state 0. The unstable species, F−
2 and F−
3 have intermediate oxidation states which decompose at around 40 K;93 F+
4 and a few related species are predicted to be stable.94 Experimental evidence for the fluoronium ion, where fluorine has oxidation state +1, was reported in 2013.95
- The metastable boron and nitrogen monofluoride have higher-order fluorine bonds, and some metal complexes use it as a bridging ligand. Hydrogen bonding is another possibility.
4 melts at 932 °C (1710 °F),108 HfF
4 sublimes at 968 °C (1774 °F),105 and UF
4 melts at 1036 °C (1897 °F).109
- These thirteen are those of molybdenum, technetium, ruthenium, rhodium, tungsten, rhenium, osmium, iridium, platinum, polonium, uranium, neptunium, and plutonium.
- See also the explanation by Clark.127
- Carbon tetrafluoride is formally organic, but is included here rather than in the organofluorine chemistry section – where more complex carbon-fluorine compounds are discussed – for comparison with SiF
4 and GeF
- Perfluorocarbon and fluorocarbon are IUPAC synonyms for molecules containing carbon and fluorine only, but in colloquial and commercial contexts the latter term may refer to any carbon- and fluorine-containing molecule, possibly with other elements.
- This terminology is imprecise, and perfluorinated substance is also used.157
- This DuPont trademark is sometimes further misused for CFCs, HFCs, or HCFCs.
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|Periodic table (Large version)|
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