4-aminobutyrate transaminase

4-aminobutyrate transaminase
Identifiers
Symbol	ABAT
Entrez	18
HUGO	23
OMIM	137150
RefSeq	NM_020686
UniProt	P80404
Other data
Locus	Chr. 16 p13.2

4-aminobutyrate transaminase
Identifiers
EC number	2.6.1.19
CAS number	9037-67-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search
PMC	articles
PubMed	articles
NCBI	proteins

In enzymology, 4-aminobutyrate transaminase (EC 2.6.1.19), also called GABA transaminase or 4-aminobutyrate aminotransferase, is an enzyme that catalyzes the chemical reaction:

4-aminobutanoate + 2-oxoglutarate $\rightleftharpoons$ succinate semialdehyde + L-glutamate

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 4-aminobutanoate:2-oxoglutarate aminotransferase. This enzyme participates in 5 metabolic pathways: alanine and aspartate metabolism, glutamate metabolism, beta-alanine metabolism, propanoate metabolism, and butanoate metabolism. It employs one cofactor, pyridoxal phosphate.

Structural Studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1OHV, 1OHW, 1OHY, 1SF2, 1SFF, 1SZK, 1SZS, 1SZU, and 2EO5.

Scott EM, Jakoby WB (1959). "Soluble gamma-aminobutyric-glutamic transaminase from Pseudomonas fluorescens". J. Biol. Chem. 234 (4): 932–936. PMID 13654294.
Aurich H (1961). "Ueber die beta-Alanin-alpha-Ketoglutarat-Transaminase aus Neurospora crassa". Hoppe-Seyler's Z. Physiol. Chem. 326: 25–33.
Schousboe A, Wu JY, Roberts E (1973). "Purification and characterization of the 4-aminobutyrate:2-ketoglutarate transaminase from mouse brain". Biochemistry 12 (15): 2868–73. doi:10.1021/bi00739a015. PMID 4719123.